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A New Threat In Osteoporosis
August 8, 2004 --A recently identified risk factor for osteoporosis is thought to be credible and important. Homocysteine is used by the body to make proteins and is known as an amino acid. Normal levels are important for proper body function. However, elevated levels of homocysteine have recently been linked to an increased risk of heart disease and dementia. Now, it appears that abnormally elevated homocysteine levels place a patient at risk for osteoporosis and hip fracture.
Researchers from Holland studied 2406 men and women over 55 years of age for up to eight years1. As the level of homocysteine rose, the incidence of fracture increased. A level of homocysteine in the highest quarter of measured values doubled the risk of fracture. Another study from Boston also found that increased levels of homocysteine increased hip fracture in the 2000 men and women studied2.
"These findings suggest that homocysteine concentration, which is easily modifiable by dietary intervention, is an important risk factor for hip fracture in older persons," concluded the investigators, who are affiliated with Tufts, Boston and Harvard University. Consuming folic acid and B vitamins is an excellent way to reduce homocysteine levels. "Although it is difficult to decipher whether elevated homocysteine levels are a marker for bone thinning and osteoporosis or whether the elevations are due to the effects of homocysteine acting directly to weaken bone, it is worthwhile to note this as a modifiable risk factor for osteoporosis and await further study," states John A. Sunyecz, M.D., founder and president of MenopauseRx, Inc.
Reference:
1: The New England Journal of Medicine 2004;350:2033-2041.
2: The New England Journal of Medicine 2004;350:2042-2049.
Copyright ©2004 content, MenopauseRx, Inc. The information provided by MenopauseRx, Inc. is not intended to replace the medical advice of your doctor or health-care provider. Please consult your health-care provider for advice about a specific medical condition.
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